Overweight children with fatty liver disease sharply reduced the amount of fat and inflammation in their livers by cutting soft drinks, fruit juices and foods with added sugars from their diets, a rigorous new study found.

The new research, published in JAMA on January 22, suggests that limiting sugary foods and drinks may be a promising lifestyle strategy to help alleviate a devastating condition linked to the obesity crisis that is spreading rapidly in adults and children.

An estimated 80 million to 100 million Americans have non-alcoholic fatty liver disease, which causes the liver to swell with dangerous levels of fat. Roughly seven million of those are adolescents and teenagers.

Fatty liver disease typically has few symptoms, and many people who have it don’t know it.

But fatty liver disease raises the risk of developing Type 2 diabetes and heart disease, and it can progress to a more severe condition called non-alcoholic steatohepatitis, or NASH, which is a leading cause of liver cancer, cirrhosis and liver transplants.

Healthy Diet and Exercise

Current guidelines call for children who have fatty liver disease to exercise and eat a healthy diet though they do not specify particular foods.

But some experts already counsel their fatty liver patients to avoid added sugars, which manufacturers commonly add to heavily processed foods and which are different than the sugars that occur naturally in foods like fruit.

Added sugars are typically high in fructose, which can ramp up the production of new fat when it is metabolised by the liver.

"The current standard of care is very similar to what we would recommend for any child that is overweight,” said Dr. Miriam Vos, an author of the new study and an assistant professor of paediatrics at the Emory University School of Medicine.

"Unfortunately, that general recommendation hasn’t improved the disease as much as we would like, and there are no large randomised trials looking at which diet is the best one for fatty liver.”

For the new study, Vos and her colleagues recruited 40 children, about 13 years old on average, who had fatty liver disease.

Most were Hispanic, a group that has a particularly high prevalence of fatty liver disease, with an average of between 21% and 25% liver fat, more than four times the normal limit.

Study

The researchers then randomly assigned the children to one of two diet groups for eight weeks.

One group limited added sugars, and the second group of children, which served as the control, remained on their usual diets. They were not given any special instructions to avoid or lower sugar.

To make the diet easier and more practical for the children in the limited-sugar group to follow, the researchers asked their families to follow it as well.

They tailored the diet to the needs of each household by examining the foods they consumed in a typical week and then swapping in lower sugar alternatives.

If a family routinely ate yogurts, sauces, salad dressings and breads that contained added sugar, for example, then the researchers provided them with versions of those foods that did not have sugar added to them.

Fruit juices, soft drinks and other sweet drinks were forbidden. They were replaced with unsweetened iced teas, milk, water and other non-sugary beverages.

Dietitians prepared and delivered meals to the families twice a week, which helped them stick to their programs.

Ultimately, the low-sugar diet was not terribly restrictive. It was not low-carb, nor was it limited in calories. The children could eat fruit, starches and pasta, for example, and they were allowed to eat as much as they wanted.

But the goal was to get their added sugar intake to less than 3% of their daily calories — less than the 5% to 10% limit for adults and children recommended by the World Health Organization.

Findings

After eight weeks, the low-sugar group had gotten their added sugar intake down to just 1% of their daily calories, compared to 9% in the control group. They also had a remarkable change in their liver health.

They had a 31% reduction in liver fat, on average, compared to no change in the control group. They also had a 40% drop in their levels of alanine aminotransferase, or ALT, a liver enzyme that rises when liver cells are damaged or inflamed.

"As a practicing hepatologist, I see children weekly with fatty liver, and I would love to see this kind of improvement in my patients,” said Vos. "The exciting part was not only did the fat go down, but their liver enzymes also improved. That suggests that they also got a reduction in inflammation.”

The new study was funded in part by the Nutrition Science Initiative, a non-profit research group that was co-founded by the science and health journalist Gary Taubes, a proponent of low-carb diets. The National Institutes of Health, the University of California, San Diego, Children’s Healthcare of Atlanta and Emory University also provided funding.

Dr. Joel E. Lavine, an expert who was not involved in the study, said it was cleverly done and demonstrated "some important points about what a major constituent of diet contributes to this problem in terms of liver fat and inflammation and cell injury.”

He said the ubiquity of unhealthy foods makes such a diet difficult to follow, but that as a general rule doctors should advise patients and their families to check food labels for added sugars and to avoid or eliminate juices.

"The best diet, to make it very simple, is to shop the outside aisles in supermarkets and stay away from the middle aisles containing processed foods that come in boxes, cans and packages,” said Lavine.

The members of the low-sugar group lost about three pounds during the study, which may have contributed to their improvements in liver health. But Dr. Jeffrey B. Schwimmer, an author of the study, said it was unlikely to account for the large changes.

"The children on the low sugar diet did lose a few pounds on average, but that amount of weight loss has never been associated with this degree of improvement,” said Schwimmer, a professor of paediatrics at the University of California, San Diego, and the director of the Fatty Liver Clinic at Rady Children’s Hospital in San Diego. He and his co-authors are doing follow-up analyses to find out more about what accounted for the liver changes.

"This is a step, it’s not the final word,” Schwimmer said. "But based on this, we would envision studies that look at whether this therapy can actually treat the disease well enough to prevent cirrhosis, end-stage liver disease and liver cancer.”

The New York Times